3^rd International Conference on Hypertension and Healthcare August 24-25, 2018 Tokyo, Japan

Biography:

Chacón-Lozsán presently working at Critical care resident at Caracas University Hospital and an active member at  European Society of Cardiology Council on Hypertension. Also, have an experience at Pediatrics resident at Caracas University Hospital and Nephrologist, Intensivist at Caracas University Hospital.

Abstract:

Background: Hypertension is an important risk factor for cardiovascular events, stroke and kidney disease, optimal hypertension control still a controversial subject in medical literature, several studies proposed the hypertension control calculating hemodynamic parameters.

Materials and Methods: In the present study we recruited 84 patients’ males (34%) and females (49%) between 32 and 95 years of age with non-controlled hypertension taken 2 or more medications and measured heart rate (HR), systolic (SBP), diastolic (DBP) and mean (MAP) blood pressure, pulse pressure (PP), cardiac index (CI) using Liljestrand & Zander modified formula to calculate stroke volume (CI = [HR*(PP/MAP)]/Body surface area), central venous pressure (CVP) using inferior vena cava diameter (IVCD), systemic vascular resistance index (SVRi = MAP/CI*80) and divided in six hemodynamic groups Hyperdynamics (Hd) were those with CI >

3,5L/min/m2, High Resistance (Hr) group when SVRi > 2500 dynas, Fluid overload (FO) when CVP > 8 cm H2O or IVCD > 2 cm and mixed types, Hd + Hr, Hd + FO and Hr + FO, a basal value was measured after 1 week washout with captopril, after washout treatment

was selected according to hemodynamic groups with a 6 month follow up.

Results: We found a statistically significant reduction of all parameters at the first month after treatment and hypertension control according to European of Society Cardiology guidelines in 100% of patients at 3rd month of treatment with hemodynamic normalization, only Hd + FO at 6th month, with no symptomatic hypotension.

Conclusion: Hemodynamic guided treatment to control high blood pressure had good results in this study; however, bigger trials are

needed to prove his efficacy.

Biography:

Chris Elliott is a Fellow of the UK Royal Academy of Engineering and a barrister (= trial lawyer) specializing in regulated technology. He has wide experience of the development of leading-edge technology products and their regulatory approval. For the last 7 years, he has specialized in the innovative measurement of blood pressure and the clinical exploitation of the results.

Abstract:

For many patient’s hypertension is asymptomatic, often called “the silent killer”. Early detection and treatment can massively reduce mortality but need an accurate measurement. For most people that is not possible, either because they cannot visit a medical practitioner or, even if they could, because consultations are hurried and rare with little time for a proper measurement of resting BP.

Emerging technologies can change this. BP measurement using sensors and software built into the ubiquitous smartphone can be medically accurate and free to the user. When coupled with telehealth consultations, it opens up a new vision of hypertension management. When used with other sensors already in the smartphone, the diagnosis extends to cardiac volume, arrhythmias, single-lead ECG, and heart valve timing.

The author’s company is conducting clinical trials of a device that is small enough and cheap enough to be bundled with every smartphone, so opening up the prospect of 1 billion people per year gaining this capability at no direct cost, just as the camera in the phone imposes no direct cost. All of the measurements meet accepted accuracy standards because they use mature techniques – Riva-Rocci but with no cuff for blood pressure, infrared detection for body temperature, pulse oximetry for blood oxygen and others. The device is already in quantity production and is expected to be widely available in 2019.

LMD’s sensor delivers actionable and reliable data to the user and clinician and has the potential to change hypertension management globally.

Biography:

Muhammad Nabeel Dookhun is currently undergoing his MD in Cardiology at The First Affiliated Hospital of Nanjing Medical University. He is working with a team responsible to conduct basic and clinical research. So far he has already published several papers. He is also members of several International Medical organizations and also the co-founder of International Medical Hub.
 

Abstract:

To evaluate the relationship between hypertension and stem cell factor (SCF)/c-kit in depressive patients. Methods: A total of 147 hypertensive patients from the Psychiatric and Neuropsychiatry department of the Jiangning Second People’s Hospital from February 2013 to December 2013 were divided into two groups according to the presence and absence of depression; control group (n=70, hypertensive patients without depression) and study group (n=77, hypertensive patients with depression). 37 cases from the study group were chosen for antidepressant therapy and were sub-grouped as the treatment group. Peripheral SCF/c-kit levels were measured by Enzyme-Linked ImmunoSorbent Assay. Circulating endothelin-1 (ET-1) and interleukin 6 (IL-6) in peripheral blood were determined by radio-immunity assay. Results: The expressions of SCF/c-kit, ET-1 and IL-6 differed significantly between hypertensive patients with and without depression (SCF: 848±22 vs 917±32 ng/L; c-kit: 11.9 ± 3.7 vs 13.1 ± 4.1 μg/L; ET-1: 165± 21 vs 151±17 ng/L; IL-6: 97.3 ± 12.1 vs 86.2 ± 9.8 ng/L) (all P< 0.05). The expression of SCF/c-kit, ET-1 and IL-6 were significantly different prior and post-treatment (SCF: 852±19 vs 873±25 ng/L; c-kit: 11.4 ± 3.5 vs. 12.7 ± 3.1 μg/L; ET-1: 166±20vs 140±15 ng/L; IL-6: 97.9 ± 11.4 vs 46.5 ± 9.7 ng/L (all P< 0.05). Logistic regression analysis indicated that lower levels of SCF/c-kit, higher levels of ET-1 and IL-6 (OR/P value of 24.779/0.002; 79.998/0.001; 27.688/0.013; 198.343/0.000 respectively) were influencing risk factors of hypertension with depression. Conclusion: Peripheral SCF/c-kit levels are significantly lower in hypertensive patients with depression than those without depression. After the antidepressant therapy, peripheral SCF/c-kit levels are increased in hypertensive patients with depression.

Biography:

Sang Soo Kim had focused at his research area to establish the pathogenesis of diabetes and its complication and to identify novel methods for early diagnosis and treatment of diabetic complications at Pusan National University Hospital. And he had participated in a number of randomized clinical trials as principal investigator or sub-investigator. Especially, he had published a number of original articles related to diabetic complication (diabetic nephropathy and neuropathy) in the peer-reviewed international journal. As a visiting scholar, he had conducted experimental studies for hypothalamic metabolism at a division of Endocrinology and Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School for 2 years. 

Abstract:

The increasing number of people with diabetes has had a major impact on the prevalence of diabetic kidney disease, which is a metabolic disorder with high morbidity and mortality and is the leading cause of end-stage renal disease (ESRD). To improve the lives of people with DKD and to reduce the impact on society, early identification of the development or progression of DKD using appropriate screening and diagnostic tools is very important in order to provide timely and proper management. Albuminuria is considered as a sensitive marker of chronic kidney disease (CKD) and CVD risk and is used as the first clinical indicator of DKD. Although the presence of urinary albumin is recognized as an early marker of DKD, the significant glomerular damage has already occurred by the time albuminuria is apparent. It has been suggested that non-albumin proteinuria (NAP), rather than albuminuria, might be an important biomarker for early detection of the de­velopment and progression of DKD. We recently demonstrated that urinary NAP might be a sensitive and specific marker of tubular damage that predicts renal impairment in type 2 diabet­ic patients. Furthermore, non-albumin proteinuria showed additional value over and above that of albuminuria for predicting the progression of CKD in patients with type 2 diabetes. Whereas, there is no doubt that hypertension plays a pivotal role in developing DKD. Thus, the role of the NAP as biomarkers in hypertensive disorder might be considered quite interesting in the future.

Biography:

Natasha Setiabakti has completed her medical doctor from Universitas Indonesia (2017) and honors degree from Monash University (2015). She is now doing her social service internship in rural areas in Indonesia. She has interest in the cardiovascular system and has two papers in a reputed international journal in that topic. Apart from that, she is also interested in social and charity work, she had attended more than 30 social works nationally. 

Abstract:

Hypertension has been the leading risk factor for various cardiovascular diseases. Worldwide, more than one in six people suffer from hypertension. The theory had suggested that black tea, a very popular beverage around the globe, has a positive effect on cardiovascular protection and can reduce blood pressure. Thus, this report focuses on the effect of black tea consumption on blood pressure. An internet-based literature search was done through three electronic databases (Ovid Medline, PubMed, and EBSCOHost. Using the keyword “black tea” and “hypertension”, applying various filters and reviewing the abstract, 2 promising studies were used in this report.  One meta-analysis by Liu, et al showed that long-term consumption of black tea significantly reduces the mean average of systolic and diastolic BP. A similar result was also reported by Grassi, et al that stated that intake of two glasses of black tea for eight consecutive days reduces the BP. Black tea had significantly reduced the BP and can be recommended to the hypertensive patient. However, consumption of black tea cannot replace anti-hypertensive drug due to its small effect.

Biography:

Tsabang Nolé has completed his Ph.D. at the age of 48 years from Yaounde 1 University. Author of 50 articles and principal investigator of four books published by Heifer International Project Cameroon, he has accomplished 31 years of research and has higher education experience including teaching and consulting. Besides Biodiversity and ethnopharmacological research, Dr. Tsabang Nolé teaches the following undergraduate and graduate courses: Ecophysiology, Sustainable development, Ethnobotany and socio-economic aspects of Agroforestry, Ethnopharmacology and Traditional medicine, as an adjunct lecturer at the Faculty of Medicine and Biomedical Science, at the University of Dschang and at the Higher Institute of Environmental Sciences

Abstract:

In Africa as for many other diseases, diagnosis of high blood pressure is delayed often with complications and very high blood pressure values. In comparison with European subjects, the high blood pressure in South Saharan-African subjects, has a higher prevalence, is more severe, develops earlier, with a higher percentage of target organ complications that include strokes, renal failure, and heart failure.  The prevalence of high blood pressure is increasing among black Africans living on the African continent, who have neglected the African way of life or among Africans migrating to Western countries. All these particularities are linked to two factors: aggravating role of environment that reacts together with ethnic predisposition. African beliefs such as curse, evil spirits, witchcraft, bewitchment, social problems and the worship of the death, create psychological fear which can maintain high hypertensive values in patients. The present study helps to identify and document medicinal hypotensive plants, sociocultural ways of local therapists to resolve psychological problems and how avoid environmental aggravation. We have conducted an ethnomedical and ethnopharmacological survey nearby 1131 interviewers living in 58 socio-cultural groups random distributed in ecosystems of Cameroon. Seventy-four herbal medicines used to fight against essential and secondary hypertensions, base on 83 plants, were recorded. The local therapists’ role in management of psychological problems was also revealed. This work may help to reduce African hypertension prevalence and give hope to black subjects of hypertension. Herbal medicines which will be more effective in the management of hypertension will be exploited in drugs’ discovery worldwide.

Biography:

Prof Dewan Majid has completed his Ph.D. from Leeds University, England, the UK and postdoctoral studies from the Department of Physiology, Tulane University School of Medicine, New Orleans, LA, USA prior to joining as a faculty member in the same department in Tulane University. He is now the Professor of Physiology and the Director of Mouse Phenotyping Core of the Tulane Hypertension and Renal Center of excellence. He has published more than 70 full papers and review articles in reputed journals and has served as an editor/editorial board member of many national and international journals including American Journal of Physiology, Hypertension etc.

Abstract:

Normally, superoxide (O₂^-) remains at minimal levels in tissues as it reacts with nitric oxide (NO) to form peroxynitrite (ONOOˉ). Although studies have demonstrated a reciprocal regulation of renal tubular sodium (Na+) reabsorption by NO and O₂^-, the specific role for ONOOˉ in the regulation of renal sodium excretion is not yet clearly defined. It has been demonstrated that an interaction between NO and O₂^- forming ONOOˉ plays an important reno-protective role in the kidney which helps to prevent excessive tubular Na+ reabsorption in conditions such as in elevated renin-angiotensin system. However, its regulation in various pathophysiological conditions, particularly in salt-sensitive hypertension is not yet clarified. The ONOOˉ formation is increased by angiotensin II (AngII) as well as by high salt (HS) intake as both of these stimulate both NO and O₂^- production. However, conditions such as impairment in NOS activity, its pharmacological inhibition or gene deletion, reduces the formation of ONOOˉ. Recent findings that chronic AngII with HS intake results in aggravated hypertension and renal injury in endothelial NO synthase knockout mice (a model for minimal ONOOˉ formation) compared to those in wild-type mice that suggest a protective role for ONOOˉ in these adverse effects of AngII.  This talk will present evidence from different studies in our laboratory and others implicating the functional roles of ONOOˉ in a coordinated regulation of kidney function, an imbalance of which could be involved in the pathophysiology of salt-sensitive hypertension.

Biography:

Helvaci, Mehmet Rami completed his Doctor of Medicine at  Marmara University, Turkey. He worked as an Assistant doctor in internal medicine at  Mersin University, Turkey from 2000—2004, later as an assistant professor in Dumlupinar University Hospital, Kutahya, Turkey, since 2005. He was a member of hematology department Baskent University, Turkey in the year of 2004—2005.

Abstract:

Background: We tried to understand the significance of white coat hypertension (WCH), clinically.

Methods: We took consecutive patients with underweight in the first phase, and age-matched consecutive patients with normal weight, overweight, and obesity were taken in the second phase of the study.

Results: Although we were able to detect 50 cases in the underweight group with a mean age of 24.7 years, we were only able to detect nine age-matched cases in the obesity group, thus the obesity group was not taken for comparison. There were gradual and statistically significant increases in the prevalences of WCH beside the gradual and significant decreases in the sustained normotension (NT) from the underweight towards the normal weight and overweight groups. Eventually, only 31.8% of the overweight cases have sustained NT although the very young mean age of them.

Conclusions: Due to the gradually increased prevalences of WCH from the underweight towards the normal weight and overweight groups and the very low prevalence of sustained NT in the overweight group although the very young mean age of them and the already known increased prevalences of hypertension, impaired fasting glucose, impaired glucose tolerance, type 2 diabetes mellitus, hypertriglyceridemia, hyperbetalipoproteinemia, dyslipidemia, coronary artery disease, chronic obstructive pulmonary disease, cirrhosis, chronic renal disease, and stroke and an increased all-cause mortality rate in the same direction, WCH may actually be an acute phase reactant mainly alarming overweight and obesity and many associated health problems in future

Biography:

Background and objectives: It is noted, that today the population of Uzbekistan unprecedentedly increases consumption of salt and have low physical activity in general. The purpose of our research was in developing the prognostic model of the turnpike arteries biological age of hypertensive patients.

Material and Methods: The study included 30 healthy volunteers and 450 men with arterial hypertension AH in the average age of 56.06 ± 7.86 years, diagnosed abdominal obesity (BMI 34.54 ± 3.83 kg/m2) and metabolic disorders.

Result: On the basis of local research grant analysis the calculator of risk was developed to provide patients with AH I-II - degrees the important prognostic information. We also considered that population of modern Uzbekistan have tendencies of negative impact at vessels damage such as salt and the increased body weight. As a result nine best factors for stratification of risk in patients with the defect vessels and raised SBP, including easy available, clinical parameters were included in this calculator. We applied multistage stratification of risk, based on 9 parameters which were included in the developed equation of nine factors: (a+b+s+d) x e / 100 / 2 + (*m+i-18) (a-SBP; b- IM complex; s- Salt; d-smoking; e-age; *m- metabolic index *m= tx g / h²; i-BMI; t- Triglycerides, g- Glucose; h- HDL-C). During this experiment, patients noted the informational content of the calculator for the objective comprehension of their cardiovascular status (Sensitivity–85 %, Specificity–63%). However long-term preventive effect, in the prevention of the recurrence was not confirmed (Fig.1,2).

Conclusion: On completion of the therapy clinical tests indicated the high sensitivity at average specificity model that was acceptable in an opportunity to estimate the medical effect. Unfortunately, the calculator could show the rate of damage vessels in the cases of an actual disease, but not in cases of its prediction or probable emergency. 

Abstract:

Aleksandr V. Nagay et al is the founder and creator of this prognostic model conception. His model has been created by the results of researching 450 Uzbek population patients with AH for eight years. The risk calculator has been developed from the multiplex analysis and provides important prognostic information in ambulatory patients with AH receiving contemporary guideline-recommended therapy. The 9 best predictors for risk stratification in patients with AH and metabolic syndrome, including easily obtainable clinical characteristics and salt-sensitivity, have been included for this calculator. This calculator assesses the risk for three endpoints of the trial: chronological distance, biological age of vessels and residual risk.