Day 1 :
Keynote Forum
Masahiro Onuma
President of Trisguide ltd Japan
Keynote: Electronic water can reduce oxidative stress in cancer and diabetes patients for 3 weeks drinking.
Biography:
Masahiro Onuma has expertise in oxidative disease prevention to use non-medical product based on GSK’s experience of Allopurinol which is the strongest anti-oxidant efficacy in this world. He creates new indication of Allopurinol for stomatitis induced by cancer treatment which was approved by the Japanese Cancer treatment committee to propose new mechanism of Allopurinol for anti-oxidant. And now, there are so many new research papers of Allopurinol in the world.
Abstract:
Oxidative stress means a state there is imbalance between the oxidizing action and the reducing action due to reactive oxygen species (ROS) in a living body, resulting in the oxidizing action becoming dominant. Oxidative stress arises as the balance between production and removal is disrupted through excessive production of ROS and impairment of the antioxidant system. Oxidative stress has been reported to be involved in the onset and progress of various diseases. Characteristics of Type 2 diabetes are insulin secretion failure and insulin resistance, but it seems that oxidative stress is greatly involved in insulin secretion failure. In the insulin secretion-inducing β cells of Langerhans islets in the pancreas, the amount of superoxide dismutase (SOD), which is representative of the ROS elimination system, is small and resistance to oxidative stress is considered to be weak. Regarding cancer, it is well known that chronic inflammatory conditions increase the risk of carcinogenesis. Cells such as neutrophils and macrophages are activated in the inflammation area leading to increase in production of active oxygen and nitric oxide. These free radicals cause DNA mutation and cell proliferation thereby promoting cancer development. When chronic inflammation is present, cancer develops more easily.
Electronic water, which was developed to generate electron in water, was consumed for three weeks, after meals, between meals and before sleeping 6 times a day, and according to the test subjects' possible time periods. The amount of drinking water was 750-1000 mL, and BAP and d-ROMs checks for all cases were carried out at 4:30 pm. The results of cancer patients and diabetes patients were seen as attached.
As a result, the d-ROMs value in the degree of oxidative stress has reduced, and the BAP value, which is an indicator of plasma antioxidant capacity, has improved significantly.
Keynote Forum
Jeanette N Ramakuela
University of Venda, School of Health Science
Keynote: Healthcare Literacy of Diabetic Mellitus Chronic Complications Among Diabetic Patients: A Rural South Africa Perspective.
Time : 10 :15- 11:30 A.M
Biography:
Nditsheni J Ramakuela is a healthcare Professional who specialized in community health care and sexuality of women. Her PhD Model is entitled “A MODEL TO FACILITATE WOMEN’S COPING WITH MENOPAUSE”. Her model is being utilised by rural community based women to help cope with menopausal challenges they encounter. She is also a lecturer in the university providing teaching and learning to undergraduate students while supervising research to both masters and PhD students and other postgraduate students from other universities from outside. She has more than 20 year’s clinical and teaching experience from the hospitals, clinic, college and university. Through her experience she developed passion for general nursing conditions and disorders and currently facilitating such to 3rd level undergraduate students at University of Venda. She is an active researcher who publishers papers every year in accredited journals and receive excellence in research awards yearly. Travels in and around the country to present scientific research papers at national and international conferences. She also empowers rural community women with reproductive health issues.
Abstract:
Problem Statement: Diabetic care is a lifelong responsibility, and careful management and early treatment strategies may reduce the risk of complications. A profound need for an improvement in the awareness of diabetes management and its complications in the primary healthcare sectors is a dire requirement. Inadequate health literacy can cause difficulties in understanding diabetic chronic complications. Individuals with poorer health literacy have difficulty interpreting medication warning labels, following directions on a prescription label and identifying their complications. Difficulties in understanding and performing health-related activities may ultimately lead to poorer health outcomes. The study intended to assess health literacy of diabetic mellitus chronic complications among diabetic patients at selected rural hospitals of South Africa.
This study employed a quantitative, typical descriptive, non-experimental approach using cross-sectional descriptive designs. Seven hospitals, 3 health Centres and 12 clinics were selected for the study. Whilst, the population were 259 diabetic patients in the province. Patients diagnosed with diabetes, above 18 years admitted between April –November 2016 in medical units of selected hospitals. A self-designed self-administered questionnaire was used to collect data. Data were analyzed using SPSS Version 20.0. Validity and reliability and ethical considerations were adhered to. Findings revealed that access to health services, treatment, and behavioral factors was found to challenge amongst diabetic patients and was perceived to be contributing to inadequate health literacy regarding diabetic complications. Conclusion & Significance: Patients with diabetic complications require adequate Knowledge and health services within their reach. Recommendations: the use of mobile clinics to provide services to remote villages, and home-care visits to diabetic patients in remote communities for continuing literacy.
- Hypertension
Session Introduction
Chacón-Lozsán F
Caracas University Hospital,Venezuela
Title: Hemodynamic Management of High Blood Pressure
Biography:
Chacón-Lozsán presently working at Critical care resident at Caracas University Hospital and an active member at European Society of Cardiology Council on Hypertension. Also, have an experience at Pediatrics resident at Caracas University Hospital and Nephrologist, Intensivist at Caracas University Hospital.
Abstract:
Background: Hypertension is an important risk factor for cardiovascular events, stroke and kidney disease, optimal hypertension control still a controversial subject in medical literature, several studies proposed the hypertension control calculating hemodynamic parameters.
Materials and Methods: In the present study we recruited 84 patients’ males (34%) and females (49%) between 32 and 95 years of age with non-controlled hypertension taken 2 or more medications and measured heart rate (HR), systolic (SBP), diastolic (DBP) and mean (MAP) blood pressure, pulse pressure (PP), cardiac index (CI) using Liljestrand & Zander modified formula to calculate stroke volume (CI = [HR*(PP/MAP)]/Body surface area), central venous pressure (CVP) using inferior vena cava diameter (IVCD), systemic vascular resistance index (SVRi = MAP/CI*80) and divided in six hemodynamic groups Hyperdynamics (Hd) were those with CI >
3,5L/min/m2, High Resistance (Hr) group when SVRi > 2500 dynas, Fluid overload (FO) when CVP > 8 cm H2O or IVCD > 2 cm and mixed types, Hd + Hr, Hd + FO and Hr + FO, a basal value was measured after 1 week washout with captopril, after washout treatment
was selected according to hemodynamic groups with a 6 month follow up.
Results: We found a statistically significant reduction of all parameters at the first month after treatment and hypertension control according to European of Society Cardiology guidelines in 100% of patients at 3rd month of treatment with hemodynamic normalization, only Hd + FO at 6th month, with no symptomatic hypotension.
Conclusion: Hemodynamic guided treatment to control high blood pressure had good results in this study; however, bigger trials are
needed to prove his efficacy.
Dr Chris Elliott
Leman Micro Devices , Switzerland
Title: Impact of ubiquitous blood pressure monitoring
Biography:
Chris Elliott is a Fellow of the UK Royal Academy of Engineering and a barrister (= trial lawyer) specializing in regulated technology. He has wide experience of the development of leading-edge technology products and their regulatory approval. For the last 7 years, he has specialized in the innovative measurement of blood pressure and the clinical exploitation of the results.
Abstract:
For many patient’s hypertension is asymptomatic, often called “the silent killer”. Early detection and treatment can massively reduce mortality but need an accurate measurement. For most people that is not possible, either because they cannot visit a medical practitioner or, even if they could, because consultations are hurried and rare with little time for a proper measurement of resting BP.
Emerging technologies can change this. BP measurement using sensors and software built into the ubiquitous smartphone can be medically accurate and free to the user. When coupled with telehealth consultations, it opens up a new vision of hypertension management. When used with other sensors already in the smartphone, the diagnosis extends to cardiac volume, arrhythmias, single-lead ECG, and heart valve timing.
The author’s company is conducting clinical trials of a device that is small enough and cheap enough to be bundled with every smartphone, so opening up the prospect of 1 billion people per year gaining this capability at no direct cost, just as the camera in the phone imposes no direct cost. All of the measurements meet accepted accuracy standards because they use mature techniques – Riva-Rocci but with no cuff for blood pressure, infrared detection for body temperature, pulse oximetry for blood oxygen and others. The device is already in quantity production and is expected to be widely available in 2019.
LMD’s sensor delivers actionable and reliable data to the user and clinician and has the potential to change hypertension management globally.
Muhammad Nabeel Dookhun
The First Affiliated Hospital of Nanjing Medical University, Mauritius
Title: The relationship between hypertension and stem cell factor/c-kit in depressive patients
Biography:
Muhammad Nabeel Dookhun is currently undergoing his MD in Cardiology at The First Affiliated Hospital of Nanjing Medical University. He is working with a team responsible to conduct basic and clinical research. So far he has already published several papers. He is also members of several International Medical organizations and also the co-founder of International Medical Hub.
Abstract:
To evaluate the relationship between hypertension and stem cell factor (SCF)/c-kit in depressive patients. Methods: A total of 147 hypertensive patients from the Psychiatric and Neuropsychiatry department of the Jiangning Second People’s Hospital from February 2013 to December 2013 were divided into two groups according to the presence and absence of depression; control group (n=70, hypertensive patients without depression) and study group (n=77, hypertensive patients with depression). 37 cases from the study group were chosen for antidepressant therapy and were sub-grouped as the treatment group. Peripheral SCF/c-kit levels were measured by Enzyme-Linked ImmunoSorbent Assay. Circulating endothelin-1 (ET-1) and interleukin 6 (IL-6) in peripheral blood were determined by radio-immunity assay. Results: The expressions of SCF/c-kit, ET-1 and IL-6 differed significantly between hypertensive patients with and without depression (SCF: 848±22 vs 917±32 ng/L; c-kit: 11.9 ± 3.7 vs 13.1 ± 4.1 μg/L; ET-1: 165± 21 vs 151±17 ng/L; IL-6: 97.3 ± 12.1 vs 86.2 ± 9.8 ng/L) (all P< 0.05). The expression of SCF/c-kit, ET-1 and IL-6 were significantly different prior and post-treatment (SCF: 852±19 vs 873±25 ng/L; c-kit: 11.4 ± 3.5 vs. 12.7 ± 3.1 μg/L; ET-1: 166±20vs 140±15 ng/L; IL-6: 97.9 ± 11.4 vs 46.5 ± 9.7 ng/L (all P< 0.05). Logistic regression analysis indicated that lower levels of SCF/c-kit, higher levels of ET-1 and IL-6 (OR/P value of 24.779/0.002; 79.998/0.001; 27.688/0.013; 198.343/0.000 respectively) were influencing risk factors of hypertension with depression. Conclusion: Peripheral SCF/c-kit levels are significantly lower in hypertensive patients with depression than those without depression. After the antidepressant therapy, peripheral SCF/c-kit levels are increased in hypertensive patients with depression.
Sang Soo Kim
Pusan National University Hospital, Korea
Title: Non-albumin proteinuria as biomarker for early diabetic kidney disease: beyond albuminuria
Biography:
Sang Soo Kim had focused at his research area to establish the pathogenesis of diabetes and its complication and to identify novel methods for early diagnosis and treatment of diabetic complications at Pusan National University Hospital. And he had participated in a number of randomized clinical trials as principal investigator or sub-investigator. Especially, he had published a number of original articles related to diabetic complication (diabetic nephropathy and neuropathy) in the peer-reviewed international journal. As a visiting scholar, he had conducted experimental studies for hypothalamic metabolism at a division of Endocrinology and Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School for 2 years.
Abstract:
The increasing number of people with diabetes has had a major impact on the prevalence of diabetic kidney disease, which is a metabolic disorder with high morbidity and mortality and is the leading cause of end-stage renal disease (ESRD). To improve the lives of people with DKD and to reduce the impact on society, early identification of the development or progression of DKD using appropriate screening and diagnostic tools is very important in order to provide timely and proper management. Albuminuria is considered as a sensitive marker of chronic kidney disease (CKD) and CVD risk and is used as the first clinical indicator of DKD. Although the presence of urinary albumin is recognized as an early marker of DKD, the significant glomerular damage has already occurred by the time albuminuria is apparent. It has been suggested that non-albumin proteinuria (NAP), rather than albuminuria, might be an important biomarker for early detection of the development and progression of DKD. We recently demonstrated that urinary NAP might be a sensitive and specific marker of tubular damage that predicts renal impairment in type 2 diabetic patients. Furthermore, non-albumin proteinuria showed additional value over and above that of albuminuria for predicting the progression of CKD in patients with type 2 diabetes. Whereas, there is no doubt that hypertension plays a pivotal role in developing DKD. Thus, the role of the NAP as biomarkers in hypertensive disorder might be considered quite interesting in the future.
Natasha M Setiabakti
Universitas Indonesia
Title: The Effect of Black Tea Consumption in Reducing Blood Pressure
Biography:
Natasha Setiabakti has completed her medical doctor from Universitas Indonesia (2017) and honors degree from Monash University (2015). She is now doing her social service internship in rural areas in Indonesia. She has interest in the cardiovascular system and has two papers in a reputed international journal in that topic. Apart from that, she is also interested in social and charity work, she had attended more than 30 social works nationally.
Abstract:
Hypertension has been the leading risk factor for various cardiovascular diseases. Worldwide, more than one in six people suffer from hypertension. The theory had suggested that black tea, a very popular beverage around the globe, has a positive effect on cardiovascular protection and can reduce blood pressure. Thus, this report focuses on the effect of black tea consumption on blood pressure. An internet-based literature search was done through three electronic databases (Ovid Medline, PubMed, and EBSCOHost. Using the keyword “black tea” and “hypertension”, applying various filters and reviewing the abstract, 2 promising studies were used in this report. One meta-analysis by Liu, et al showed that long-term consumption of black tea significantly reduces the mean average of systolic and diastolic BP. A similar result was also reported by Grassi, et al that stated that intake of two glasses of black tea for eight consecutive days reduces the BP. Black tea had significantly reduced the BP and can be recommended to the hypertensive patient. However, consumption of black tea cannot replace anti-hypertensive drug due to its small effect.
Tsabang Nolé
Universities in Cameroon, Cameroon
Title: Ethnomedical and ethnopharmacological aspects and sociocultural treatment of African high blood pressure in Cameroon
Biography:
Tsabang Nolé has completed his Ph.D. at the age of 48 years from Yaounde 1 University. Author of 50 articles and principal investigator of four books published by Heifer International Project Cameroon, he has accomplished 31 years of research and has higher education experience including teaching and consulting. Besides Biodiversity and ethnopharmacological research, Dr. Tsabang Nolé teaches the following undergraduate and graduate courses: Ecophysiology, Sustainable development, Ethnobotany and socio-economic aspects of Agroforestry, Ethnopharmacology and Traditional medicine, as an adjunct lecturer at the Faculty of Medicine and Biomedical Science, at the University of Dschang and at the Higher Institute of Environmental Sciences
Abstract:
In Africa as for many other diseases, diagnosis of high blood pressure is delayed often with complications and very high blood pressure values. In comparison with European subjects, the high blood pressure in South Saharan-African subjects, has a higher prevalence, is more severe, develops earlier, with a higher percentage of target organ complications that include strokes, renal failure, and heart failure. The prevalence of high blood pressure is increasing among black Africans living on the African continent, who have neglected the African way of life or among Africans migrating to Western countries. All these particularities are linked to two factors: aggravating role of environment that reacts together with ethnic predisposition. African beliefs such as curse, evil spirits, witchcraft, bewitchment, social problems and the worship of the death, create psychological fear which can maintain high hypertensive values in patients. The present study helps to identify and document medicinal hypotensive plants, sociocultural ways of local therapists to resolve psychological problems and how avoid environmental aggravation. We have conducted an ethnomedical and ethnopharmacological survey nearby 1131 interviewers living in 58 socio-cultural groups random distributed in ecosystems of Cameroon. Seventy-four herbal medicines used to fight against essential and secondary hypertensions, base on 83 plants, were recorded. The local therapists’ role in management of psychological problems was also revealed. This work may help to reduce African hypertension prevalence and give hope to black subjects of hypertension. Herbal medicines which will be more effective in the management of hypertension will be exploited in drugs’ discovery worldwide.