Nagay AV
Republican Specialized Center of Cardiology, Uzbekistan
Biography
Background and objectives: It is noted, that today the population of Uzbekistan unprecedentedly increases consumption of salt and have low physical activity in general. The purpose of our research was in developing the prognostic model of the turnpike arteries biological age of hypertensive patients.
Material and Methods: The study included 30 healthy volunteers and 450 men with arterial hypertension AH in the average age of 56.06 ± 7.86 years, diagnosed abdominal obesity (BMI 34.54 ± 3.83 kg/m2) and metabolic disorders.
Result: On the basis of local research grant analysis the calculator of risk was developed to provide patients with AH I-II - degrees the important prognostic information. We also considered that population of modern Uzbekistan have tendencies of negative impact at vessels damage such as salt and the increased body weight. As a result nine best factors for stratification of risk in patients with the defect vessels and raised SBP, including easy available, clinical parameters were included in this calculator. We applied multistage stratification of risk, based on 9 parameters which were included in the developed equation of nine factors: (a+b+s+d) x e / 100 / 2 + (*m+i-18) (a-SBP; b- IM complex; s- Salt; d-smoking; e-age; *m- metabolic index *m= tx g / h2; i-BMI; t- Triglycerides, g- Glucose; h- HDL-C). During this experiment, patients noted the informational content of the calculator for the objective comprehension of their cardiovascular status (Sensitivity–85 %, Specificity–63%). However long-term preventive effect, in the prevention of the recurrence was not confirmed (Fig.1,2).
Conclusion: On completion of the therapy clinical tests indicated the high sensitivity at average specificity model that was acceptable in an opportunity to estimate the medical effect. Unfortunately, the calculator could show the rate of damage vessels in the cases of an actual disease, but not in cases of its prediction or probable emergency.